ZEB1 and osteoporosis: This hydrogel can introduce ZEB1 gene plasmid into endothelial cells by releasing Lip-ZEB1, so that the ZEB1 gene can be integrated into the genome of endothelial cells, thereby activating the ZEB1/Notch signal pathway of endothelial cells, promoting vascular regeneration and bone regeneration, and ultimately promoting the local bone reconstruction of osteoporosis by genetic engineering.