These alterations can leadto constitutive activation of EGFR signaling, promoting uncontrolledcell growth and tumor progression and inhibiting apoptotic processes.4 Activated EGFR signaling can suppress apoptosisby increasing the expression of antiapoptotic proteins, such as Bcl-2and Bcl-xL, and decreasing the expression or activity of pro-apoptoticproteins like Bax and Bak. Here, EGFR is linked to neoplasm.