Additionally, while the Hannum clock very often showed unexpected directions of effect in TILDA, the DNAm‐metabolic clock showed expected directions of effect with all health outcomes, including marginal associations with CVD (odds ratio: 1.25, 95% CIs [0.97, 1.61]) and depression (odds ratio: 1.34, 95% CIs [0.95, 1.9]) (Figure 6A). Here, CLOCK is linked to major depressive disorder.