The severity of liver disease and parameters of systemic inflammation were higher in Group 1 (any TTTc) than in Group 2 (MELD: 25.5 vs. 20.8, P < .001; MDF: 59.3 vs. 40.6, P < .001; WBC count: 12.7 vs. 7.6, P < .001; relative neutrophil count: 79.6 vs. 72.9, P < .001; CRP concentration: 34.1 vs. 23.3, P = .001). This evidence concerns the gene CRP and liver disorder.