IFNG and neoplasm: Remarkably, the most strikingly downregulated cytokine was IFN‐γ, a central player in anti‐tumor immunity.[36] To ascertain whether these macrophages on high matrix rigidity exert a functionally tumor‐favorable effect against T cell proliferation and activation, we treated pre‐stimulated primary human T cells with the CM from BMDMs for 3 days (Figure 8A).