Conducting a cytokine array of conditioned media (CM) from IL4/13‐treated BMDMs cultured on either 1 or 100 kPa PA gels (Figure 8A), our analysis revealed that BMDMs cultured on rigid substrates released higher levels of pro‐tumoral cytokines, including tissue inhibitor of metalloproteinase 1 (TIMP‐1), Progranulin, C‐C motif chemokine ligand 7 (CCL7), and angiopoietin‐related protein 3 (ANGPTL3), all implicated in cancer cell migration, proliferation, and angiogenesis (Figure 8B,C, Data S4, Supporting Information). The gene discussed is TIMP1; the disease is cancer.