When WT or Tm4sf5−/− (KO) C57BL/6 mice were administered with DEN+CCl4, liver weights and spleen sizes were not different between animal groups; but tumor volume and nodule diameter (>1.0 mm) were greater in WT mice than in KO mice under DEN+CCl4 treatment, although the treatment did not significantly change their levels in KO mice (Supplementary Fig. S2b and S2c). Here, TM4SF5 is linked to neoplasm.