TM4SF5 and neoplasm: Presumably due to the immune-rejection activity in immune-competent C57BL/6 mice, we might not have more and greater tumor nodules, although the SNU449T7 cells (with human TM4SF5 overexpression) have been shown to have an aggressive tumor-initiating cell property.30 The livers with tumors formed via TM4SF5-mediated SNU449T7 showed lower Slamf7 expression, which was slightly recovered by TSI treatment (Supplementary Fig. S8c).