This result may be due to TM4SF5’s involvement not only in HCC but also in pre-cancerous liver features, including MASH-associated fibrosis.23,25 These cancerous effects were not seen in DEN-treated Tm4sf5−/− mice or in TG mice treated with DEN and ST-2-001 (Fig. 1k). The gene discussed is TM4SF5; the disease is hepatocellular carcinoma.