Although we found the specific linkage between hepatocyte TM4SF5 expression and SLAMF7 downregulation on NK cells, we further wondered whether TM4SF5-specific inhibition might lead to inhibiting of TM4SF5-mediated tumor formation in immune-deficient mice via downregulations of TM4SF5-mediated signaling activities. The gene discussed is TM4SF5; the disease is neoplasm.