P2RY13 and early-onset autosomal dominant Alzheimer disease: The two identified microglial aging genes, P2ry13 and Slc16a3, are also found to be down- and up-regulated, respectively, in the so-called disease-associated microglia (DAM) that are found in Alzheimer’s disease as well as other neurodegenerative disorders [69, 91, 92].