Moreover, CCR2+ monocytes have been identified in the degenerative IVDs from herniation patients and constitute the majority of CD11b+ and F4/80+ cells.39 However, as reported in myocardial infarction model,40 loss of CCR2 expression is required for fibrocyte differentiation of the infiltrated monocytes. This evidence concerns the gene CCR2 and myocardial infarction.