SPI1 and lymphoma: As for lymphoma cell autophagy, comparing with the untreated group, LC3B expression remained constant in PU.1-knockdown SC1 co-culture system (Fig. 3f), while increased in PU.1-overexpressing DOHH2 co-culture system upon lenalidomide treatment (P = 0.013, Fig. 3g), in consistent with amount of typical autophagosomes in lymphoma cells (Figs. 3h, i).