B2M and neoplasm: A high ratio of CD4+ T cells to CD8+ T cells, increased amounts of PD-1 positive tumor-infiltrating T cells, as well as signal regulatory protein alpha (SIRPα+) and colony stimulating factor-1 receptor (CSF1R+) macrophages were associated with inferior PFS, while higher amounts of GATA binding protein 3 (GATA3+) T helper were associated with good prognosis.20,21 Here, we first reported that clinical risk factors of elevated serum β2m and lymph node >6 cm translate to poor response to lenalidomide-containing immunotherapy.