ENO1 activates mitophagy by increasing the acetylation level of YWHAZ, leading to a decrease in its ubiquitination level and the inability for YWHAZ to be degraded, an increase in the stability of YWHAZ and thus an increase in its binding to Parkin, which further inhibits the degradation of Parkin, leading to an increase in the ability of MM cells to clear damaged mitochondria. The gene discussed is PRKN; the disease is Miyoshi myopathy.