BCL2 and varicocele: Navitoclax’s modulation of these key proteins supports the hypothesis that Acorus tatarinowii’s beneficial effects rely on the BCL2 pathway, highlighting its potential as a targeted therapy for oligoasthenozoospermia by directly influencing apoptotic regulation.This finding is reinforced by studies where pathway-focused bioinformatic analyses were applied to uncover cell division cycle genes as well as apoptotic factors in varicocele, highlighting potential therapeutic targets for male infertility [29].