In line with this, confocal analyses displayed a P4HA1 signal in the area of the pancreatic tumor lesion negative for the epithelial marker E-cadherin (E-Cad) and for the pancreatic epithelial tumor Pan-cytokeratin (PanCK) and a co-localization with the CAF marker alpha-smooth muscle actin (aSMA) (Fig. 2D), supporting the hypothesis of a specific P4HA1 role in the stromal compartment. This evidence concerns the gene P4HA1 and pancreatic neoplasm.