P4HA1 and neoplasm: Here, it has been shown that isolated D-hpCAFs retain memory of dysmetabolism increasing P4HA1 expression and consequently its enzymatic function, as demonstrated by hydroxyproline increased levels (Fig. 3C), ultimately enhancing collagen deposition and contraction (Fig. 3B and D), thus stroma development, which might explain the higher PDAC aggressiveness in dysmetabolic patients partly due to absence of tumor T lymphocyte infiltration.