These results supports data obtained in the present research work, where P4HA1 immuno-modulatory role has been demonstrated associated with a higher stroma deposition of dysmetabolic-dependent PDAC desmoplasia by wet laboratory experiments (Fig. 2 and Fig. 3), thus linking its well-known enzymatic activity in collagen biosynthesis to establish a physical barrier preventing T lymphocyte infiltration and ultimately anti-tumoral response in PDAC, one of the cold tumor by definition [71, 72]. Here, P4HA1 is linked to neoplasm.