Indeed, Kaplan–Meier curve related to total P4HA1 expression generated exploiting PDAC transcriptomics data deposited in The Cancer Genome Atlas (TCGA) data sets showed an interesting inverse correlation of high P4HA1 expression with PDAC patient life expectancy [24, 25, 64], highlighting its prognostic value and prompting to further keep P4HA1 under the spotlight as crucial molecular player of pancreatic cancer stroma evolution (Fig. 2B). This evidence concerns the gene P4HA1 and familial pancreatic carcinoma.