STAT3 knockout reduced tumor-eradicating phenotypes and anti-tumoral hybrids by 33% but decreased pro-tumoral phenotypes (M2c) by 63%, mediated via NF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upchi$$\end{document}χB activation. The gene discussed is STAT3; the disease is neoplasm.