The concentration of 2 cytokines was greater in the BAL of COPD mice exposed to CS + AFsp: TNF-α, a pro-inflammatory cytokine and potent neutrophil recruiter [22], as well as IL-10, a modulator of neutrophilic influx in the airways and of TNF-α expression [27]. The gene discussed is IL10; the disease is chronic obstructive pulmonary disease.