EZR and ductal breast carcinoma in situ: In IBC cases, elevated ezrin H score values were notably linked to high tumor grade (p = 0.002), high N stage (p = 0.045), advanced AJCC stage grouping (p = 0.043), presence of metastasis (p = 0.001), higher grade (p = 0.033), and a greater extent of DCIS and perineural invasion (p = 0.031) (Fig. 5).