CHI3L1 and neoplasm: CHI3L1 interacts with multiple receptors (Fig. 3), such as RAGE, IL-13Rα2, and syndecan-1/αVβ3, triggering pathways involved in inflammasome activation, neuronal inflammation, tumor progression, angiogenesis, apoptosis, and amyloid-beta (Aβ) accumulation [98].