The cumulative risk of CRC at 75 years is 46%, 43%, and 15% for path_MLH1, path_MSH2, and path_MSH6 carriers, respectively, while the cumulative incidence of CRC at 80 years is 13% for men and 12% for women among PMS2 mutation carriers [7, 8]. The gene discussed is MSH6; the disease is colorectal carcinoma.