PDGFRA and hepatocellular carcinoma: Interestingly, on the one hand these PDGFRα+ CAFs that we identified in HCC tissue exhibit an immunosuppressive characteristics; on the other hand we find evidence that these PDGFRα+ CAFs may be derived from HPCs, which suggests that HPC-derived PDGFRα+ CAFs may participates in the construction of an ISME during hepatocarcinogenesis.