Su et al. reported that CD10+GPR77+ CAFs promote tumour formation and chemoresistance by providing a survival niche for cancer cells [7]; Ye et al. reported that myofibroblast CAFs secrete an extracellular matrix that specifically limits the natural killer secreted extracellular matrix and natural killer (NK) cell cytotoxicity to promote tumour growth [8]. Here, C5AR2 is linked to neoplasm.