Additionally, in the context of Alzheimer’s disease (AD) neuroinflammation, lncRNA MALAT1 downregulates the expression of IL-6 and TNF-α while concurrently enhancing IL-10 levels, suggesting the potential therapeutic value of targeting lncRNA MALAT1 in AD [53]. The gene discussed is MALAT1; the disease is early-onset autosomal dominant Alzheimer disease.