The MSH2 SV found in patient #97 (c.2620_2621ins[G;2507_2620]) was detected in a patient (patient #A) with prostate cancer (Fig. 6A) and lack of MSH2 and MSH6 expression in the tumor tissue verified the pathogenic nature of this variant concerning this malignancy (Fig. 6B). The gene discussed is MSH2; the disease is Familial prostate cancer.