MSH6 and Familial prostate cancer: The MSH2 SV found in patient #97 (c.2620_2621ins[G;2507_2620]) was detected in a patient (patient #A) with prostate cancer (Fig. 6A) and lack of MSH2 and MSH6 expression in the tumor tissue verified the pathogenic nature of this variant concerning this malignancy (Fig. 6B).