Therefore, the activation of intracellular signaling cascades such as Phosphoinositide 3-kinase (PI3K), Mitogen-activated protein kinase (MAPK), and the Janus kinase signal transducer and activator of transcription (JAK-STAT) pathway, which are involved in carcinogenesis, tumor growth, and regulation of other cytokines, is inhibited. The gene discussed is WNK2; the disease is neoplasm.