As shown in Fig. 6J–L and Fig. S5A–C, reconstitution of DUB3 WT in endogenous DUB3-deficient cells markedly increased cell proliferation and desensitized cancer cells to cisplatin, whereas reconstitution of the T495A mutant failed to affect YAP1 protein level and displayed a strong suppressive effect on ovarian cancer cells. This evidence concerns the gene USP17L2 and ovarian carcinoma.