The lessons learned from TSC in the search for EEG-based biomarkers might extend to other neurodevelopmental disabilities as well, since there is a high prevalence of seizures in many neurodevelopmental disabilities such as Rett Syndrome (60–80% [6]), Fragile X Syndrome (20% [1]), 22q11.2 Deletion Syndrome (11% [7]), CDKL5 Deficiency Disorder (nearly 100% [1]), autism (12% [8]) and others. Here, CDKL5 is linked to Neurodevelopmental abnormality.