Notably, among the seven CpG sites liked to the diabetes progression, five showed a negative correlation with gene expression levels, including cg23436042, cg11183227 (MAN2A2), cg06500161 (ABCG1), cg06710464 (BAIAP2), and cg17058475 (CPT1A), while cg08788930 (DENND3) and cg11311053 (NCOR2) did not. Here, DENND3 is linked to diabetes mellitus.