In contrast, six CpG sites (cg10442325, cg15418499 annotated to IL18, cg20507228, annotated to MAN2A2, cg04334723 annotated to calreticulin (CALR), cg20661985 and cg00574958 annotated to CPT1A) exhibited a slower decrease in methylation change over time for individuals with T2D compared to those with NGT. Here, CALR is linked to type 2 diabetes mellitus.