Notably, these 7 CpG sites, including cg23436042, cg11183227 annotated to MAN2A2, cg06500161 annotated to ABCG1, cg08788930 annotated to DENN domain-containing protein 3 (DENND3), cg11311053 annotated to nuclear receptor corepressor 2 (NCOR2), cg06710464 annotated to BAR/IMD domain containing adaptor protein 2 (BAIAP2), and cg17058475 annotated to CPT1A, demonstrated associations with both persistent and progressed diabetes status. The gene discussed is DENND3; the disease is diabetes mellitus.