In our follow-up study, we considered the evolving nature of diabetes status and identified seven methylation sites linked to the progression from NGT to prediabetes and T2D: cg23436042, cg11183227 (MAN2A2), cg06500161 (ABCG1), cg08788930 (DENND3), cg11311053 (NCOR2), cg06710464 (BAIAP2), and cg17058475 (CPT1A). This evidence concerns the gene DENND3 and diabetes mellitus.