IFNA2 and neoplasm: As shown in Fig. S8, A–C, treatment with IFN-α, SHP099, or H89 alone caused an effective inhibition of tumor weight, with reduction of about 48%, 40.8%, and 15.2%, respectively, whereas treatment with IFN-α in combination with SHP099 and H89 synergistically inhibited tumor growth, reducing it by approximately 82.6% and 77.2%, respectively.