To validate the expression of these eight genes of interest in APAs, we analyzed a Gene Expression Omnibus (GEO) dataset (GSE60042) [33], which showed that NR4A2, EGR1, FOS, and ABCC3 gene expression was downregulated in APA tumor tissue compared to the adjacent cortex, whereas CYP11B2 and DUSP4 were upregulated (Fig. 2F). This evidence concerns the gene NR4A2 and neoplasm.