VEGFA and necrotizing enterocolitis: A clinical trial involving 128 VLBW infants and 200 healthy term neonates showed that VLBW infants had a higher occurrence of the VEGF + 405C allele compared to the healthy group.251 Meanwhile, the VEGF-2578A allele, which is linked to reduced VEGF gene expression, was identified as an independent risk factor for NEC.