Jiang et al. (2019) demonstrated that HOTTIP suppression inhibited the Wnt/β-catenin pathway leading to reduced CDK4, cyclin D1, and β-catenin expressions; consequently, the development of PCa cell and cell cycle will be inhibited; moreover, the sensitivity of the cells to cisplatin will be enhanced (Jiang et al. 2019) (Table 3). This evidence concerns the gene CCND1 and posterior cortical atrophy.