AXL and neoplasm: Because we posit that AXL has both tumor cell intrinsic and extrinsic functions in mediating a MES cell state, and it appears that AXL signaling alone is not a major oncogenic drive of the MES cell state, we explored ADCT-601, an AXL-targeted ADC, which contains a potent pyrrolobenzodiazepine dimer toxin to explore MES-specific therapeutic targeting.