CD276 and neuroblastoma: Monoclonal antibodies, ADCs, and CARs specific to B7-H3 are being explored in preclinical and clinical studies.18–21 GPC2 is a glypican protein anchored to the cell surface that was discovered as an oncogene in neuroblastoma and has been targeted with ADC and a CAR T-cell approaches,22–25 including an ongoing clinical trial (NCT05650749).