To investigate the effect of ADAR1 on TMZ‐induced autophagy, we combined ADAR1‐knockdowned cells with ADAR1 overexpression and control cells with TMZ in two glioma cell lines and used Western blotting to detect the expression of the LC3 protein and the p62 protein, which are related to autophagy. This evidence concerns the gene ADAR and central nervous system cancer.