APOE and early-onset autosomal dominant Alzheimer disease: For example, those with the highest 10% polygenic risk score values have nearly a 1.9-fold increase in the risk of late-onset Alzheimer’s disease compared with those in the lowest 10%, and this effect is additive to age and the apolipoprotein E (APOE) status, with the latter being the gene most strongly associated with late-onset Alzheimer’s disease (Bellenguez et al., 2022).