APOE and early-onset autosomal dominant Alzheimer disease: Other studies have shown a potential role of a late-onset Alzheimer’s disease-derived polygenic risk score in predicting EOAD cases, though differences in age of participants and APOE status may confound direct comparisons (Cruchaga et al., 2018; de Rojas et al., 2021; Fulton-Howard et al., 2021; Huq et al., 2021).