NEFL and Alzheimer disease: In particular, NfL has been implicated in a wide range of neurodegenerative conditions (Bacioglu et al., 2016), including late-onset Alzheimer’s disease (Mattsson et al., 2017), frontotemporal dementia (Rohrer et al., 2016) and amyotrophic lateral sclerosis (Gaiani et al., 2017).