APOE and Norrie disease: In determining which variables would discriminate between all neurodegenerative cases (combining EOAD and nAD-ND) and PPD, the best model (Model 1C) contained seven variables: age at assessment, APOE ε2 and ε4 status, global cognitive function, polygenic risk score, p-tau181 and sex (Supplementary Table 13, Supplementary Figure 4C), yielding an AUC = 0.984 [95% CI: 0.960–1.000].