ANG and metabolic disease: In line with this finding, another study reported the crucial rule of modified sperm tsRNAs by zygotic injection of 30–40 nt RNAs (predominantly 5′-tsRNAs) from angiogenin-mediated inflammatory males and non-modified synthetic 5′-tsRNAs and found that non-modified synthetic 5′-tsRNAs only partially resembled the paternal inflammation-induced metabolic disorders in offspring.