Both MOLM-13 and MV-4-11 cell lines are MLL-rearranged and FLT3-ITD mutant, whereas HL-60 cells have a TP53 deletion, and mutations in CDKN2A and NRAS. Thus, hypoxia can influence HMA responses, but the pathways impacted by hypoxia may depend on AML genotype and differ between DAC and AZA. The gene discussed is KMT2A; the disease is acute myeloid leukemia.