Traditional tumor markers, such as Carcinoembryonic Antigen (CEA), Squamous Cell Carcinoma Antigen (SCC), Cytokeratin-19 Fragment Antigen 21 − 1 (CYFRA 21 − 1), and Gastrin-releasing Peptide Precursor (ProGRP), have limited sensitivity and specificity in diagnosing small nodules due to their limited secretion capabilities [3–5]. The gene discussed is SERPINB3; the disease is neoplasm.