In a murine model of skin inflammation, it has been demonstrated that TXA2 generated by blood platelets, through TP receptor activation, induces the synthesis of the proinflammatory cytokine interleukin 6 and PGE2, and also suppresses the expression of the anti-inflammatory marker, mannose receptor C type 1 (CD206) in macrophages [206]. This evidence concerns the gene MRC1 and dermatitis.