Our findings suggest that astrocytic dysfunction is more prominent than any abnormal innate immune response at this stage of the disease, as IL-6 and IL-8 levels, which are upregulated in HD and correlate with disease progression49,50, remained unchanged longitudinally, reinforcing the importance of treating early at this stage, before widespread neuroinflammation occurs. This evidence concerns the gene CXCL8 and Huntington disease.