More intriguingly, sirius red staining revealed increased collagen fibers in the mouse liver with SLC13A2 deficiency (Fig. 6H), indicating suppressed regenerative capacity resulted in hepatocyte injury and hepatic fibrosis, especially under chronic damaging conditions (Haideri et al, 2017; Li et al, 2023a). This evidence concerns the gene SLC13A2 and Hepatic fibrosis.