For example, in our study, several key contributors for PC-1 (MIP-1β, TNF-α, MCP-1, IP-10, IL-1RA, GM-CSF) were significantly associated baseline cognition but not cognitive decline, suggesting these inflammatory biomarkers either play important roles in accumulative chronic systemic inflammation or are responsive to early pathological changes, or both. The gene discussed is CCL2; the disease is Mental deterioration.