Firstly, in the bidirectional MR analysis, we observed a genetically predicted significant inverse causal association between ILD and IPF and BRSK2(ILD: βIVW = 0.145, p = 2.28 × 10–4; IPF: βIVW = 0.083, p = 2.56 × 10–3), Further Q-tests and pleiotropy tests revealed evidence of heterogeneity (IPF: pQ = 1.15 × 10–27, ppleiotropy = 0.01; ILD: pQ = 1.15 × 10–18, ppleiotropy = 0.03). The gene discussed is BRSK2; the disease is interstitial lung disease.