Specifically, higher plasma levels of LTBR(Lymphotoxin-beta receptor) were associated with a significantly increased risk of developing sarcoidosis, with on average 39% increased risk(OR = 1.39; p = 9.38 × 10−6), while ANGPTL4(Angiopoietin-related protein 4)(OR = 0.72; p = 1.68 × 10–5), VEGFB(Vascular endothelial growth factor B) (OR = 0.21; p = 3.49 × 10–13) and ANXA11(Annexin A11) (OR = 0.16; p = 1.09 × 10–7) were associated with decreased risk, respectively(refer to Table 2 and Fig. 2). The gene discussed is ANXA11; the disease is sarcoidosis.