Moreover, islet-infiltrating CD8+ T cells from T1D patients recognized HLA-B40-restricted granule peptides, notably derived from the known β-cell antigens INS, CHGA, SCG5, the newly described ATP-binding cassette subfamily C member 8 (ABCC8) and carboxypeptidase E (CPE), and glutathionylated KIF1A. This evidence concerns the gene CPE and type 1 diabetes mellitus.