IFNA1 and type 1 diabetes mellitus: To this end, we first screened 101 T-cell receptors (TCRs), sequenced from islet-infiltrating CD8+ T cells of 4 HLA-B40+ T1D organ donors29 from nPOD (Supplementary Table 3) and re-expressed into ZsGreen-NFAT fluorescent reporter 5KC T cells30, against 29 HLA-B40-restricted peptides derived from granule proteins and detected in IFN-α-treated β-cells (Supplementary Table 4).