FASN and colorectal carcinoma: The upregulation of the FABP4/UCP2 axis and subsequent increase in the levels of adipogenic markers (FASN and PPAR-γ) in the CTX-DTP CRC cells upon coculture with adipocytes indicated the importance of this axis in promoting adipogenesis in persister cells during their interaction with adipocytes, leading to their transformation into treatment-tolerant persister cells in CRCs (Fig. 6D).