EGFR and colorectal carcinoma: Through a comprehensive analysis using the R DSeq2 package, we identified FABP4, UCP2, and EGFR as key differentially expressed genes (DEGs), as evidenced by their elevated expression levels in cetuximab-resistant CRC samples compared with cetuximab-sensitive ones; the results for these DEGs are presented in a heatmap, volcano plot, and line graph, respectively (Fig. 3A).