FABP4 and colorectal carcinoma: The schematic protocol for the in vitro co-culture experiment of CTX-DTP CRC cells and 3T3-L1 adipocytes is illustrated in Fig. 6A. The CTX-DTP CRC cells cocultured with adipocytes exhibited significant activation of the FABP4/UCP2 signaling axis, which was closely associated with the development of resistance to cetuximab treatment.