BRAF and cutaneous melanoma: Comprehensive genome profiling (CGP) has revealed common oncogenic variants in BRAF, NRAS, and NF1 in cutaneous melanomas, with a mean TMB of 17 variants/Mb and a ultraviolet radiation signature.11 This study of cutaneous melanomas also identified co-occurring or mutually exclusive gene alterations accompanied by these driver variants, suggesting the existence of complex regulatory networks in melanoma oncogenesis.