The variant patterns in Japanese SKCM were similar to those in White studies, with BRAF, NRAS, and NF1 variants being particularly prevalent in the TCGA SKCM data set, albeit at higher variant rates (Appendix Fig A3A).24 The ACRM data suggested higher susceptibility to acquired KIT variants in Asians than in White patients (Appendix Fig A3B).25 Japanese uveal melanomas exhibited a unique gene alteration landscape, with most cases showing variants in either GNAQ or GNA11, particularly at Q209 (Fig 1C, Appendix Figs A2C and A2D). This evidence concerns the gene GNAQ and uveal melanoma.