These variants were mutually exclusive and were presumed to be driver genes in Japanese uveal melanomas, similar to their roles in White melanomas (Fig 1C and Appendix Fig A3C).26BAP1 loss-of-function alterations and SF3B1 SNVs, particularly at R625, were found in over half of the uveal melanomas and may play a supplementary role in oncogenic pathology (Fig 1C and Appendix Fig A2E). The gene discussed is SF3B1; the disease is uveal melanoma.