Several studies have suggested that the predominance of acral and mucosal melanomas in Asians may affect outcomes because they harbor a lower TMB.18-20 Although BRAF-targeted therapy has similar efficacy in Asians and White patients, the overall incidence of BRAF V600E/K variants is lower in Asians, which may hamper their opportunities for targeted therapy. The gene discussed is BRAF; the disease is mucositis.