In autoimmune diseases, such as inflammatory bowel disease (IBD), SLE, and RA, T cells are considered the major effector cells.[46, 47] Previously, literature has described the dynamic regulation of clock activity in T cells.[21, 22, 48] However, it seems that any oscillations of clock genes in naïve CD4+ T cells are weak. The gene discussed is CLOCK; the disease is autoimmune disease.