CD4 and autoimmune disease: [49] Nevertheless, another report claimed that the cell‐intrinsic clock is dispensable in the naïve CD4 T cells.[23] Despite the lack of conclusive evidence of a functional clock within naïve CD4 T cells, there is clear evidence that the cell‐intrinsic clocks of autoreactive T cells regulate autoimmune diseases.[22, 25, 49] In Teffs, molecular clock gene Rev‐erb alpha in Th17 cells has been reported to control cell differentiation, development, and autoimmunity,[13, 24] yet whether there is a functional cell‐intrinsic circadian clock in Tregs is controversial.