Moreover, U0126 notably impeded the migration and invasion of HuCCT1‐shPBRM1 cells, indicating that PBRM1 exerts an anti‐tumor effect through ERK1/2 pathway inhibition, a process blocked by an extracellular signal‐regulated kinase 1/2 (ERK1/2) inhibitor (Figure 3d–e). The gene discussed is MAPK3; the disease is neoplasm.