Recent exome sequencing studies have unveiled a high prevalence of SWI/SNF subunit mutations across various cancers, with frequent occurrences of PBRM1 mutations.[16, 20] Mutations and loss of PBRM1 function have been identified in multiple tumors, with PBRM1 deletion or inactivation correlating with tumor progression, metastasis, and poor prognosis. The gene discussed is PBRM1; the disease is cancer.