[16, 21, 22, 23] PBRM1 also contributes significantly to cell cycle regulation by modulating p21 expression in response to diverse environmental stimuli.[16, 24] PBRM1 deletion has been shown to decrease IFNγ‐STAT1 signaling in murine and human renal cell carcinoma (RCC) cell lines.[25] Inactivation of PBRM1 was found to be associated with a lower immunogenic tumor microenvironment (TME) and immunotherapy resistance in an immunocompetent murine RCC model. This evidence concerns the gene PBRM1 and hereditary clear cell renal cell carcinoma.