Cells expressing the CPSF6-Rac3 NLS were less supportive of both HIV-2 and SIVmac expression, and SIVmac infection did not exhibit the same increase in infectivity as observed with HIV-1 and HIV-2 following infection of CPSF6-C-Myc NLS expressing cells (Fig 3E). This evidence concerns the gene RAC3 and infection.