Using data from different databases and the same analytical method, the result display that PPP3CA;PPP3R1 (P = 3.11×10−7, OR = 0.61), and FCG2B (P = 3.91×10−5, OR = 0.68) were re-validated a causal effect for SLE (S1 Table). This evidence concerns the gene PPP3R1 and systemic lupus erythematosus.