The results indicated that squamocin failed to decrease levels of EZH2 and MYC in UBE2Z knockdown HNSCC cell lines (Figure 6E,F), suggesting that enhancement of the UBA6‐UBE2Z cascade is responsible for squamocin‐induced degradation of both EZH2 and MYC protein. Here, UBE2Z is linked to head and neck squamous cell carcinoma.