MYC p‐T58 is recognized by E3 ubiquitin ligases and degraded by the 26S proteasome.[43] Consistently, we found that E3 ligase FBXW7 binds to the endogenous EZH2 and MYC in the two HNSCC cell lines. This evidence concerns the gene FBXW7 and head and neck squamous cell carcinoma.