Previous studies have demonstrated that in cancer, HSP90α is not only upregulated but also its ATPase activity is increased ≈50‐fold.[28] Our pan‐cancer analysis revealed that HSP90α was upregulated across multiple tumor types, and patients with elevated levels of HSP90α experienced poor prognosis, including those with HNSCC (Figure S3, Supporting Information). This evidence concerns the gene HSP90AA1 and cancer.