We matched our gene expression profile with validated or predicted E3s and DUBs targeting EZH2 and MYC using the UbiBrowser_v2 database.[38] Notably, following squamocin treatment, 23 genes encoding E3s and 17 genes encoding DUBs were found to be dysregulated in both HNSCC cell lines (Figure S6D, Table S6, Supporting Information). Here, EZH2 is linked to head and neck squamous cell carcinoma.