Similarly to our observations from HNSCC cell lines, knockdown of any of the UBA6‐UBE2Z‐FBXW7 ubiquitin cascade with specific siRNA blunted the degradation of both EZH2 and MYC in GC and CRC cell lines (Figure S7K–P, Supporting Information). Here, UBA6 is linked to head and neck squamous cell carcinoma.