The network analysis identified key genes such as PLAG1, TGFBR2, CDKN2A, MAPK14, E2F2, E2F3, SGPL1, TP53INP1, AURKB, ACVR1B, BRCA1, FEN1 and MYC highlighted by their high degrees and betweenness centrality, underscoring their essential roles in melanoma biology. This evidence concerns the gene FEN1 and melanoma.