SLC49A4 and renal carcinoma: Another linked gene associated with longevity found in the current study, DIRC2, is located in close proximity to both PARP14 and PARP9. In humans, the primary association of DIRC2 is with renal carcinoma (Bodmer et al., 2002) but the lysosomal function, in which DIRC2 plays a crucial role, is vital for cellular homeostasis and aging processes (Carmona-Gutierrez et al., 2016).