MMP2 and central nervous system cancer: BLZ-100 (tozuleristide, Blaze Bioscience Inc, Seattle, WA), also commonly known as “tumor paint,” is a conjugate of NIR with the tumor-specific peptide chlorotoxin (Patil et al., 2019), that is extracted from scorpion venom and binds to the cell surface of gliomas through the binding to matrix metalloproteinase-2 and annexin A2.